Reacción #1735072

ord-3203693e9a7b471988dc7a71f97095a1

Ecuación de reacción

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCNC(=O)c1ccc2c(c1)nc(C1CCNCC1)n2C
5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-2-(4-piperidinyl)-benzimidazole
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide
→
COC(=O)CCNC(=O)c1ccc2c(c1)nc(C1CCN(C(=N)N)CC1)n2C
2-(1-Amidino-4-piperidinyl)-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole

Reactantes

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCNC(=O)c1ccc2c(c1)nc(C1CCNCC1)n2C
5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-2-(4-piperidinyl)-benzimidazole
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide

Reactivos

Ninguno

Disolventes

CN(C)C=O
dimethylformamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared from 5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-2-(4-piperidinyl)-benzimidazole and S-ethylisothiourea-hydrobromide by heating to 100° C. for 4 hours in dimethylformamide in the presence of sodium carbonate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05434150uspto-grants-1995_07