Reacción #1732574

Ecuación de reacción

ammonium chloride

THF

3-fluorophenylmagnesium bromide

THF

aminonitrile

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

→

[(1,4-Dioxa-spiro[4.5]dec-8-yl)-3-fluorophenyl-methyl]-dimethylamine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile cooling with ice
2. 2
   Temperaturawhile cooling with ice
3. 3
   Extracciónextracting the mixture with diethyl ether (3×100 ml)
4. 4
   LavadoThe organic phase was washed with water and saturated sodium chloride solution
5. 5
   Otrodried
6. 6
   Concentraciónconcentrated

Procedimiento

A solution of the aminonitrile 4 (23.45 g, 104 mmol) in absol. THF (100 ml) was added dropwise to a 1 M solution of 3-fluorophenylmagnesium bromide in THF (208 ml, 208 mmol) under argon and while cooling with ice, and the mixture was stirred at RT for 20 hours. The reaction mixture was worked up by adding saturated ammonium chloride solution (100 ml) and water (100 ml) while cooling with ice, and extracting the mixture with diethyl ether (3×100 ml). The organic phase was washed with water and saturated sodium chloride solution, dried and concentrated.

Fuente