Reacción #1726699

Ecuación de reacción

5-amino-2-(methylsulfanyl)-4-phenylthiazole

hydrogen peroxide

→

5-amino-2-(methylsulfinyl)-4-phenylthiazole

Rendimiento 87.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrodropwise at ambient temperature
2. 2
   OtroAfter 4 hr the mixture was partitioned between dichloromethane (60 ml) and water (60 ml)
3. 3
   OtroThe organic phase was separated
4. 4
   Lavadowashed with brine
5. 5
   Secadodried over sodium sulfate
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated in vacuo

Procedimiento

To 5-amino-2-(methylsulfanyl)-4-phenylthiazole (305 mg, 1.37 mmol) in acetic acid (3.0 ml) was added aqueous hydrogen peroxide (660 μl, 30% wt, 6.9 mmol) dropwise at ambient temperature. After 4 hr the mixture was partitioned between dichloromethane (60 ml) and water (60 ml). The organic phase was separated, washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded pure 5-amino-2-(methylsulfinyl)-4-phenylthiazole (285 mg, 87%).

Fuente