Reacción #172574

Ecuación de reacción

ethyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)benzoate

→

ethyl 2-(2-amino-3-phenylpropanoyloxy)benzoate

Rendimiento 69.3%

Disolventes

CH2Cl2

TFA

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated under reduced pressure
2. 2
   OtroThe crude material was purified by silica gel chromatography (0-10% MeOH/CH2Cl2)

Procedimiento

The ethyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)benzoate (1.2 g, 2.9 mmol) was dissolved in CH2Cl2 (10 mL) and TFA (4 mL). The reaction was stirred (RT, 3 h) and then concentrated under reduced pressure. The crude material was purified by silica gel chromatography (0-10% MeOH/CH2Cl2) to afford ethyl 2-(2-amino-3-phenylpropanoyloxy)benzoate (0.63 g). Mass calculated for C18H19NO4=313.35; found: [M+H]+=314.1

Fuente