Reacción #172547

Ecuación de reacción

2-(chlorocarbonyl)-phenyl acetate

2,4,6-trimethyl-1,3,5-trioxane

NaI

→

1-iodoethyl 2-acetoxybenzoate

Rendimiento 40.0%

Disolventes

DCM

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtrated
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   OtroThe crude was purified by silica gel chromatography (EtOAc-PE, 0-10%)

Procedimiento

To a mixture of 2,4,6-trimethyl-1,3,5-trioxane (245 mg, 1.85 mmol) and NaI (0.972 g, 6.48 mmol) in DCM (15 mL) was added a solution of 2-(chlorocarbonyl)-phenyl acetate in DCM (5 mL, 0° C.). The resulting mixture was allowed to stir (RT, 16 h). The mixture was filtrated and concentrated under reduced pressure. The crude was purified by silica gel chromatography (EtOAc-PE, 0-10%) to afford 1-iodoethyl 2-acetoxybenzoate (0.75 g, 40%) as a light yellow oil.

Fuente