Reacción #172093

Ecuación de reacción

KHSO4

benzyl 1-(methoxy(methyl)carbamoyl)cyclopropylcarbamate

LiAlH4

→

benzyl 1-formylcyclopropylcarbamate

Rendimiento 77.6%

Disolventes

water

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with EtOAc, organic layer
2. 2
   Otrowas separated
3. 3
   Lavadowashed with brine
4. 4
   Otrodried
5. 5
   Concentraciónconcentrated

Procedimiento

To a solution of benzyl 1-(methoxy(methyl)carbamoyl)cyclopropylcarbamate (1.34 g, 4.82 mmol) in THF (25 mL) at 0° C. was added LiAlH4 (366 mg, 9.64 mmol). After stirred at 0° C. for 30 min, it was poured to a solution of KHSO4 (1.9 g) in water (30 mL), extracted with EtOAc, organic layer was separated, washed with brine, dried and concentrated to give benzyl 1-formylcyclopropylcarbamate (820 mg).

Fuente