Reacción #171901

Ecuación de reacción

4′-Methyl-5-nitro-biphenyl-3-carboxylic acid

SOCl2

methanol

→

4′-Methyl-5-nitro-biphenyl-3-carboxylic acid methyl ester

Rendimiento 92.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas then heated
2. 2
   Temperaturato reflux for 2 hours
3. 3
   OtroThe solvent was removed in vacuo

Procedimiento

To a solution of 4′-Methyl-5-nitro-biphenyl-3-carboxylic acid (10.00 g, 0.039 mol) in methanol was added SOCl2 (5.09 g, 0.043 mol) at 0° C. The reaction mixture was allowed to warm to room temperature and was then heated to reflux for 2 hours. The solvent was removed in vacuo to afford 4′-Methyl-5-nitro-biphenyl-3-carboxylic acid methyl ester (9.72 g, 92%) as light yellow solid. MS (M+H)=273.

Fuente