Reacción #171816

Ecuación de reacción

7-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one

bromine

→

4,7-dibromo-3,4-dihydro-2H-benzo[b]oxepin-5-one

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was then quenched with aqueous sodium thiosulfate solution (30 mL)
2. 2
   Extracciónthe product extracted into diethyl ether (2×30 mL)
3. 3
   SecadoThe combined organics were dried (MgSO4)
4. 4
   Otropurified on silica

Procedimiento

To a solution of 7-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one (700 mg) in diethyl ether (20 mL) at 0° C. was added bromine (0.14 mL) dropwise and the reaction was stirred at room temperature for 16 h. The reaction was then quenched with aqueous sodium thiosulfate solution (30 mL) and the product extracted into diethyl ether (2×30 mL). The combined organics were dried (MgSO4), reduced in vacuo and purified on silica to give 4,7-dibromo-3,4-dihydro-2H-benzo[b]oxepin-5-one.

Fuente