Reacción #171752

Ecuación de reacción

guanidine hydrochloride

2-(2-chlorophenyl)-1-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-3-(dimethylamino)prop-2-en-1-one

potassium carbonate

→

282

5-(2-chlorophenyl)-4-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)pyrimidin-2-amine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe whole was sealed
2. 2
   Temperaturacooled to room temperature
3. 3
   Concentraciónconcentrated
4. 4
   workup.ADDITIONThe residue was diluted with water
5. 5
   Extracciónextracted with ethyl acetate
6. 6
   OtroThe combined organics were purified by reverse phase HPLC

Procedimiento

To a solution of crude 2-(2-chlorophenyl)-1-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-3-(dimethylamino)prop-2-en-1-one (ca. 0.22 mmol) in ethanol (2 mL) was added potassium carbonate (87 mg, 0.63 mmol) and then guanidine hydrochloride (40 mg, 0.42 mmol). The whole was sealed and heated at 90° C. for 8 h, cooled to room temperature and concentrated. The residue was diluted with water and extracted with ethyl acetate. The combined organics were purified by reverse phase HPLC to give 282. MS (ESI) 406.2

Fuente