Reacción #171550

Ecuación de reacción

4-bromo-1H-pyrazole

2-chloroethanol

PPh3

DEAD

→

title compound 75

4-Bromo-1-(2-chloroethyl)-1H-pyrazole

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónIt was then concentrated under reduced pressure
2. 2
   workup.ADDITIONthe residue was treated with ether
3. 3
   Filtraciónthe resultant suspension was filtered
4. 4
   OtroThe filtrate was collected
5. 5
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 4-bromo-1H-pyrazole (5 g, 34.02 mmol), 2-chloroethanol (2.7 mL, 40.82 mmol) and PPh3 (10.71 g, 40.82 mmol) and in THF (68 mL) at 0° C. was added DEAD (6.4 mL, 40.8 mmol). The mixture was allowed to warm-up to room temperature and stirred overnight. It was then concentrated under reduced pressure, the residue was treated with ether and the resultant suspension was filtered. The filtrate was collected and concentrated under reduced pressure to afford the title compound 75 which was used in the next step without further purification. MS (m/z): 209.0 (M+H).

Fuente