Reacción #171240

Ecuación de reacción

3,7,11,15-Tetramethyl-hexadecan-1-ol

sodium disulfite

chromic acid

→

title compound

Rendimiento 72.3%

3,7,11,15-tetramethyl-1-hexadecanoic acid

Rendimiento 72.3%

Disolventes

acetone

acetic acid

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroafter completion of the reaction
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature overnight
3. 3
   Extracciónextracted 6 times with diethyl ether (135 ml)
4. 4
   OtroThe solvent of the obtained organic layer was evaporated under reduced pressure
5. 5
   workup.ADDITIONDiethylether (450 ml) and water (150 ml) were added to the oil
6. 6
   Concentraciónafter concentration
7. 7
   Otroto allow partitioning
8. 8
   Extracciónthe aqueous layer was extracted 3 times with ethyl acetate (150 ml)
9. 9
   SecadoThe combined organic layer was dried over anhydrous sodium sulfate
10. 10
    Otrothe solvent was evaporated under reduced pressure
11. 11
    ConcentraciónThe oil (10.1 g) after concentration
12. 12
    Otrowas purified by chromatography (silica gel; 250 g, eluate; 50:1→3:1 hexane-ethyl acetate)

Procedimiento

3,7,11,15-Tetramethyl-hexadecan-1-ol (8.96 g, 30.0 mmol) was dissolved in a mixed solvent of acetone (360 ml) and acetic acid (180 ml), a solution of anhydrous chromic acid (7.27 g, 72.7 mmol) in water (9.0 ml) was added dropwise, and the mixture was stirred at room temperature for 1 hr. A solution of sodium disulfite (100 g, 526 mmol) in water (450 ml) was added to the reaction mixture after completion of the reaction, the mixture was stirred at room temperature overnight and extracted 6 times with diethyl ether (135 ml). The solvent of the obtained organic layer was evaporated under reduced pressure. Diethylether (450 ml) and water (150 ml) were added to the oil after concentration to allow partitioning, and the aqueous layer was extracted 3 times with ethyl acetate (150 ml). The combined organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The oil (10.1 g) after concentration was purified by chromatography (silica gel; 250 g, eluate; 50:1→3:1 hexane-ethyl acetate) to give the title compound (6.78 g, 72.3%) as a pale-blue oil.

Fuente