Reacción #170976

Ecuación de reacción

Methyl (4-nitrophenoxy)acetate

Methyl (4-Nitro phenoxy)acetate

→

22

Rendimiento 92.1%

(4-Nitrophenoxy)acetic acid

Rendimiento 92.1%

Disolventes

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtracióncrude 22 was filtered
2. 2
   Otrodried
3. 3
   Otrorecrystallised from a mixture of ethyl acetate:hexane (1:5)

Procedimiento

Methyl (4-nitrophenoxy)acetate 7 (100 g, 474 mmol) was refluxed in conc. HCl (1 L) for 8 hours. The reaction mass was cooled to room temperature and crude 22 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 22 (86 g, 92.1%) as a white shining powder with an m.p. between 186-188.5° C.

Fuente