Reacción #170968

Ecuación de reacción

methyl 6-bromohexanoate

paracetamol

K2CO3

sodium iodide

→

15

6-(4-Acetylaminophenoxy)-hexanoic acid methyl ester

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 60 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (3 L) was added
4. 4
   FiltraciónCrude 15 was filtered
5. 5
   Otrodried
6. 6
   Otrorecrystallised from a mixture of chloroform:hexane (1:5)

Procedimiento

To a mixture of paracetamol (250 gm, 1.654 mmol), anhydrous K2CO3 (800 gm, 5.789 mmol) and sodium iodide (17 g, 113 mmol) in anhydrous acetone (5 L) was added methyl 6-bromohexanoate (470 g, 2.25 mmol) and refluxed for 60 hours. Acetone was distilled off and water (3 L) was added. Crude 15 was filtered, dried and recrystallised from a mixture of chloroform:hexane (1:5) to give pure 15 (195 g, 66%) as a white powder with an m.p between 96.4-98.8° C.

Fuente