Reacción #170960

Ecuación de reacción

4-nitrophenol

K2CO3

methyl chloroacetate

→

7

Rendimiento 72.5%

Methyl (4-Nitro phenoxy)acetate

Rendimiento 72.5%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) was added
4. 4
   FiltraciónCrude 7 was filtered
5. 5
   Otrodried
6. 6
   Otrorecrystallised from a mixture of ethyl acetate:hexane (1:5)

Procedimiento

To a mixture of 4-nitrophenol (100 g, 719 mmol) and anhydrous K2CO3 (400 gm, 2.894 mol) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) was added. Crude 7 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 7 (110 g, 72.5%) as a white fluffy powder with an m.p between 97-98.4° C.

Fuente