Reacción #1707286

Ecuación de reacción

sodium hydrogen carbonate

Potassium hydroxide

iodine

5-nitroindazole

→

3-iodo-5-nitro-1H-indazole

Rendimiento 77.1%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas adjusted to room temperature
2. 2
   Filtracióna solid precipitate was collected by filtration

Procedimiento

Potassium hydroxide (6.45 g) and iodine (15.6 g) were added to a DMF (60 ml) solution containing 5-nitroindazole (5.0 g), followed by stirring at 65° C. for 1 hour. The reaction solution was adjusted to room temperature and poured into a saturated aqueous sodium hydrogen carbonate solution, a solid precipitate was collected by filtration, and a yellow solid of 3-iodo-5-nitro-1H-indazole (6.83 g) was thus obtained.

Fuente