Reacción #170707

Ecuación de reacción

[(R)-2-tert-butoxycarbonylamino-2-[1-phenyl-5-(3-propylphenyl)-1H-pyrazol-3-ylcarbamoyl]ethyl]carbamic acid tert-butyl ester

hydrogen chloride

→

titled compound

(R)-2,3-Diamino-N-[1-phenyl-5-(3-propylphenyl)-1H-pyrazol-3-yl]-propionamide dihydrochloride

Disolventes

1,4-dioxane

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThis reaction solution was concentrated
2. 2
   workup.ADDITIONn-hexane (4 ml) was added
3. 3
   workup.STIRRINGthe mixture was stirred
4. 4
   FiltraciónThe insoluble substance was collected by filtration
5. 5
   Lavadowashed with n-hexane
6. 6
   Otrodried under reduced pressure

Procedimiento

To a solution of [(R)-2-tert-butoxycarbonylamino-2-[1-phenyl-5-(3-propylphenyl)-1H-pyrazol-3-ylcarbamoyl]ethyl]carbamic acid tert-butyl ester (328 mg) in 1,4-dioxane (3 ml) was added a 4M solution of hydrogen chloride in 1,4-dioxane (3 ml) at room temperature, and the mixture was stirred for 2 hours. This reaction solution was concentrated, and then n-hexane (4 ml) was added thereto, and the mixture was stirred. The insoluble substance was collected by filtration, washed with n-hexane, and dried under reduced pressure to give the titled compound (181 mg).

Fuente