Reacción #170442

Ecuación de reacción

4-fluoroacetophenone

ethyl trifluoroacetate

sodium methoxide

→

title compound

Rendimiento 97.0%

4,4,4-Trifluoro-1-(4-fluoro-phenyl)-butane-1,3-dione

Rendimiento 97.0%

Disolventes

HCl

tertbutylmethylether

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   SecadoThe combined organic extracts were then dried over sodium sulfate
3. 3
   Otroevaporated

Procedimiento

To a solution of ethyl trifluoroacetate (23.9 mL, 199 mmol) in tertbutylmethylether (230 mL) containing sodium methoxide (5.4 M, 39.6 mL, 214 mmol) was added 4-fluoroacetophenone (25 g, 181 mmol) and the resulting mixture stirred at room temperature for 3 h and then poured into ice-water. The mixture was then diluted with HCl (2 N, 200 mL) and then extracted with ethyl acetate. The combined organic extracts were then dried over sodium sulfate and evaporated to afford the title compound (40.9 g, 97%) which was obtained as an orange oil. MS: m/e=232.9 [M−H]−.

Fuente