Reacción #170373

Ecuación de reacción

sodium hydroxide

HCl

2-fluorobenzaldehyde

hydroxylamine hydrochloride

→

title compound

Rendimiento 97.0%

2-Fluoro-benzaldehyde oxime

Rendimiento 97.0%

Disolventes

ethanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONdissolves
2. 2
   ExtracciónThe mixture was then extracted with dichloromethane

Procedimiento

To a suspension of 2-fluorobenzaldehyde (63.3 g, 495 mmol) and hydroxylamine hydrochloride (38.2 g, 544 mmol) in ethanol (36 mL) and water (69 mL) was added ice (205 g). Then an aqueous solution of sodium hydroxide (32%, 115 mL, 1.24 mol) was added dropwise within a 10 min period (temperature rises from −8° C. to +7° C.) whereupon most of the solid dissolves. After 1 h stirring at room temperature the resulting mixture was then acidified with HCl (5 N). The mixture was then extracted with dichloromethane to afford the title compound (66.8 g, 97%) which was obtained as a light yellow solid. MS m/e (EI): 139.0 [M].

Fuente