Reacción #170356

Ecuación de reacción

(5-methyl-3-phenyl-isoxazol-4-yl)-methanol

5-bromo-6-hydroxy-2-methyl-nicotinic acid ethyl ester

→

title compound

Rendimiento 76.0%

5-Bromo-2-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid ethyl ester

Rendimiento 76.0%

Condiciones de reacción

Procedimiento

As described for example 4, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (402 mg, 2.12 mmol) was converted using 5-bromo-6-hydroxy-2-methyl-nicotinic acid ethyl ester instead of 2-hydroxy-5-trifluoromethylpyridine to the title compound (SiO2, heptane:ethyl acetate=100:0 to 50:50, 700 mg, 76%) which was obtained as a colourless oil. MS: m/e=431.1/433.2 [M+H]+.

Fuente