Reacción #170349

Ecuación de reacción

2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid

4-aminotetrahydropyran

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title compound

Rendimiento 62.0%

2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-isonicotinamide

Rendimiento 62.0%

Condiciones de reacción

Procedimiento

As described for example 58c, 2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid (78 mg, 0.3 mmol) was converted, using 4-aminotetrahydropyran instead of 2,2,2-trifluoroethylamine, to the title compound (61 mg, 62%) which was obtained as a white solid. MS: m/e=394.3 [M+H]+.

Fuente