Reacción #170341
ord-c235b749b3fb4793959afaef71f0ab31
Ecuación de reacción
6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid
4,4-difluoropiperidine hydrochloride
→
title compound
Rendimiento 98.0%
(4,4-Difluoro-piperidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone
Rendimiento 98.0%
Reactantes
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 4,4-difluoropiperidine hydrochloride (1 M in DMF) instead of methylamine, to the title compound (131 mg, 98%) which was obtained as a light yellow gum. MS: m/e=414.4 [M+H]+.