Reacción #170285

Ecuación de reacción

HCl

1-hydroxy-3-(thiiran-2-ylmethoxy)-9H-thioxanthen-9-one

→

title compound

Rendimiento 71.8%

3-(3-chloro-2-mercaptopropoxy)-1-hydroxy-9H-thioxanthen-9-one

Rendimiento 71.8%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEther was added to the residue
3. 3
   Otrofollowed by sonication
4. 4
   Otrothe solvent was removed

Procedimiento

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-hydroxy-3-(thiiran-2-ylmethoxy)-9H-thioxanthen-9-one (10 mg, 0.03 mmol) prepared in Example 8, followed by stirring at room temperature for 3 hours, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (8 mg, 71.8%) as a yellow solid.

Fuente