Reacción #1702080

Ecuación de reacción

dichloromethane

acetone

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

sodium borohydride

→

desired product

Rendimiento 46.0%

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-hydroxyethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

Rendimiento 46.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe resulting solution was washed with water
2. 2
   Secadothe organic phase was dried over sodium sulfate
3. 3
   Filtraciónfiltered
4. 4
   OtroEvaporation

Procedimiento

To a solution of 5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one (65.0 mg, 0.170 mmol) from Example 5 in ethanol (1 ml) was added sodium borohydride (6.4 mg, 0.170 mmol) and the reaction mixture was stirred at room temperature over weekend. Then was added acetone (0.062 ml) followed by dilution with dichloromethane. The resulting solution was washed with water and the organic phase was dried over sodium sulfate and filtered. Evaporation gave the desired product (30 mg, 46%).

Fuente