Reacción #1702063

Ecuación de reacción

AlCl3

aluminum chloride

phenol

dichloromethane

aluminum chloride

2,5-dichloro-2,5-dimethylhexane

→

5,6,7,8-tetrahydro-2-hydroxy-5,5,8,8-tetramethyl naphthalene

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted by ethyl acetate
2. 2
   LavadoThe organic layer was washed by water
3. 3
   Secadoa saturated sodium hydrogen carbonate aq. solution, and a saturated saline solution, dried over magnesium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   OtroThe crude product was purified by recrystallization in a solvent of hexane

Procedimiento

The synthesis process is as set forth in the chemical reaction formula below. The AlCl3 in the reaction path stands for aluminum chloride. Into phenol (1.02 g, 10.8 mmol) were added anhydrous dichloromethane (5 mL), aluminum chloride (144 mg, 1.08 mmol), and 2,5-dichloro-2,5-dimethylhexane (2.18 g, 11.9 mmol) followed by stirring at room temperature for 19 hours. The reaction solution was poured into cold water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution, and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by recrystallization in a solvent of hexane. The yield was 1.83 g (83%).

Fuente