Reacción #169674

Ecuación de reacción

Amino-acetic acid 4-allyl-2-methoxy-phenyl ester

niacin

N-methyl morpholine

EDC.HCl

→

product

Rendimiento 43.0%

[(pyridine-3-carbonyl)-amino]-acetic acid 4-allyl-2-methoxy-phenyl ester

Rendimiento 43.0%

Disolventes

DCM

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water (2×100 mL)
2. 2
   Secadodried over sodium sulphate
3. 3
   OtroThe crude product obtained upon evaporation of the solvent
4. 4
   Otrowas purified by silica gel column chromatography

Procedimiento

To a solution of Amino-acetic acid 4-allyl-2-methoxy-phenyl ester (510 mg, 1.7 mmol), in DCM (20 mL) were added niacin (0.23 g, 1.9 mmol), N-methyl morpholine (0.96 mL, 8.8 mmol), EDC.HCl (0.67 g, 3.5 mmol) at ice temperature (0° C.). The mixture was allowed to stir at room temperature (25° C.) over a period of 2 hrs. The resulting mixture was diluted with DCM (200 mL) washed with water (2×100 mL) and dried over sodium sulphate. The crude product obtained upon evaporation of the solvent was purified by silica gel column chromatography to obtain product as off-white solid (210 mg, 43%).

Fuente