Reacción #169591

Ecuación de reacción

methyl 3-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)propanoate

HCl

→

methyl 3-amino-2-(4-chlorophenyl)propanoate hydrochloride

Rendimiento 178.2%

Disolventes

ether

dioxane

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford a precipitate
2. 2
   FiltraciónThe slurry was filtered under nitrogen
3. 3
   Otroto afford a white solid, which
4. 4
   Lavadowas washed with ether
5. 5
   OtroThe solid was dried under vacuum

Procedimiento

A solution of methyl 3-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)propanoate (4 mg, 1.44 mmol) in dioxane (6.0 mL) was treated with 4M HCl in dioxane (about 6.0 mL, 23.0 mmol) at room temperature. The mixture was stirred for 18 hours to completion, after which the reaction mixture was diluted with ether to afford a precipitate. The slurry was filtered under nitrogen to afford a white solid, which was washed with ether. The solid was dried under vacuum to afford the methyl 3-amino-2-(4-chlorophenyl)propanoate hydrochloride as a white solid (321 mg, 89%). LCMS (APCI+) m/z 214.0 [M+H]+.

Fuente