Reacción #1689798

Ecuación de reacción

ethyl bromoacetate

2-3

2-Oxo-3-(3-(ethylendioxy)butyl)pyrrolidine

NaN(TMS)2

→

2-4

Ethyl (2-Oxo-3-(3-(ethylendioxy)butyl)pyrrolidin-1-yl)acetate

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by removal of the cooling bath
2. 2
   workup.WAITAfter 1 h
3. 3
   workup.ADDITIONthe reaction mixture was diluted with EtOAc
4. 4
   Lavadowashed with H2O, sat. NaHCO3 and brine
5. 5
   Secadodried (MgSO4)
6. 6
   Concentraciónconcentrated

Procedimiento

To a rapidly stirred solution of 2-3 (0.86 g, 4.3 mmol) and THF (25 mL) at -78° C. was added NaN(TMS)2 (5.2 mL, 5.2 mmol, 1.0 M in THF). After 20 min, ethyl bromoacetate (0.58 mL, 5.2 mmol) was added followed by removal of the cooling bath. After 1 h, the reaction mixture was diluted with EtOAc and then washed with H2O, sat. NaHCO3 and brine, dried (MgSO4), and concentrated to give 2-4 as a yellow oil.

Fuente