Reacción #168912

Ecuación de reacción

4-(3-(bromomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine

4-cyanomethyl imidazole

cesium carbonate

→

product

Rendimiento 47.0%

2-(1-(3-(2-(4-Morpholinophenylamino)pyrimidin-4-ylthio)benzyl)-1H-imidazol-4-yl)acetonitrile

Rendimiento 47.0%

Disolventes

dimethyl formamide

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónIt was filtered
2. 2
   Otroto remove any inorganic material
3. 3
   Concentraciónthe dimethyl formamide solution was concentrated in vacuo
4. 4
   Otrochromatographed on the silica gel

Procedimiento

To a stirred mixture of 4-(3-(bromomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (100 mg, 0.22 mmol) and 4-cyanomethyl imidazole (47 mg, 0.44 mmol) in dimethyl formamide (2 mL), was added cesium carbonate (154 mg, 0.44 mmol) in one portion. The mixture was stirred at room temperature for 16 hours. It was filtered to remove any inorganic material, and the dimethyl formamide solution was concentrated in vacuo. The residue was column chromatographed on the silica gel using methanol:dichloromethane (4:96) as eluant to give the product (50 mg, 47%).

Fuente