Reacción #1689

Ecuación de reacción

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

Rendimiento 95.0%

N-Methoxycarbonylphenethylamine

Rendimiento 95.0%

Disolventes

diethyl ether

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic layer was washed with water
2. 2
   Secadodried (MgSO4)
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónthe filtrate was concentrated in vacuo

Procedimiento

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

Fuente