Reacción #168876

Ecuación de reacción

sodium thiosulfate

urea peroxide

phthalic anhydride

3-chloro-4-methoxy-2,5-dimethylpyridine

→

title compound

Rendimiento 91.5%

3-Chloro-4-methoxy-2,5-dimethylpyridine 1-oxide

Rendimiento 91.5%

Disolventes

chloroform

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder cooling on ice
2. 2
   ExtracciónThe water layer was extracted with chloroform two times
3. 3
   SecadoThe organic layer was dried over anhydrous sodium sulfate
4. 4
   workup.DISTILLATIONthe solvent was then distilled away

Procedimiento

The above 3-chloro-4-methoxy-2,5-dimethylpyridine (181 mg) was dissolved in 5 ml of dichloromethane, and urea peroxide (169 mg) and phthalic anhydride (219 mg) were then added to the solution. The resulting mixture was stirred at room temperature for 2.5 hours. Thereafter, a saturated aqueous sodium thiosulfate solution was added to the reaction solution under cooling on ice, and the resulting mixture was then diluted with chloroform. The water layer was extracted with chloroform two times. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then distilled away, so as to obtain the title compound (181 mg) as a solid.

Fuente