Reacción #1687653

Ecuación de reacción

hydrogen chloride

p-xylene

aluminum chloride

2,5-dichlorobenzoyl chloride

→

crystals

Rendimiento 94.2%

2,5-Dichloro-2',5'-dimethylbenzophenone

Rendimiento 94.2%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the addition
2. 2
   ExtracciónThe aqueous layer was extracted with ether
3. 3
   Extracciónwith ethereal extract
4. 4
   Lavadowashed with water, saturated sodium bicarbonate, brine
5. 5
   Secadorespectively, and then dried with magnesium sulfate
6. 6
   OtroAfter the removal of solvent
7. 7
   Otrothe residue was recrystallized from methanol twice

Procedimiento

To p-xylene (120 ml, 0.98 mol) was added aluminum chloride (32 g, 0.24 mol) at room temperature. To this mixture 2,5-dichlorobenzoyl chloride (30 g, 0.14 mol) was added slowly. The reaction was exothermic and hydrogen chloride evolved from the reddish solution. After the addition, the mixture was stirred for 10 min and then hydrolysed by slow addition of water. The aqueous layer was extracted with ether. The organic layer was combined with ethereal extract and washed with water, saturated sodium bicarbonate, brine, respectively, and then dried with magnesium sulfate. After the removal of solvent, the residue was recrystallized from methanol twice and then from hexane to give 36.8 g (92%) crystals (mp 58-61° C.).

Fuente