Reacción #1687652

Ecuación de reacción

o-toluoyl chloride

1,4-dichlorobenzene

Aluminum chloride

→

white crystals

Rendimiento 36.0%

2,5-Dichloro-2'-methylbenzophenone

Rendimiento 36.0%

Disolventes

Ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated to 170° C. in 30 min
2. 2
   TemperaturaThe resulting brownish solution was cooled to about 80° C.
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   OtroThe organic layer was separated
5. 5
   workup.DISTILLATIONdistilled under vacuum
6. 6
   Otroafter the removal of ether
7. 7
   workup.DISTILLATIONThe residue from distillation
8. 8
   Otrowas recrystallized twice from hexane

Procedimiento

A mixture of o-toluoyl chloride (22 g, 0.17 mol) and 1,4-dichlorobenzene (120 g, 0.82 mol) was heated to 100° C. in a flask. Aluminum chloride (60 g, 0.45 mol) was added in one portion. The mixture was heated to 170° C. in 30 min and stirred at this temperature for 3 hours. The resulting brownish solution was cooled to about 80° C. and poured onto ice. Ether (50 ml) was added. The organic layer was separated and distilled under vacuum after the removal of ether. The residue from distillation was recrystallized twice from hexane to give 16 g of white crystals (36%).

Fuente