Reacción #1687635

ord-1f3d63b3d76045508493ba53e1f22655

Ecuación de reacción

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
Cc1cnc(C2=CCCN(C)C2)s1
title compound
Cc1cnc(C2=CCCN(C)C2)s1
5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe crude free base obtained

Procedimiento

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE036374uspto-grants-1999_11