Reacción #1687622

Ecuación de reacción

12

2-Methyl-5-(3-pyridyl)-2H-tetrazole

hydrogen chloride

→

title product

Rendimiento 26.0%

2-Methyl-(3-piperidyl)-2H-tetrazole, hydrochloride

Rendimiento 26.0%

Disolventes

acetone

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrountil acidic reaction
2. 2
   FiltraciónThe precipitate was filtered off
3. 3
   Otrodried
4. 4
   workup.DISSOLUTIONdissolved in methanol (25 ml)
5. 5
   workup.ADDITION5% palladium on charcoal (0.6 g) was added
6. 6
   FiltraciónThe catalyst was filtered off
7. 7
   Otrothe filtrate was evaporated to dryness
8. 8
   OtroCrystallization from ethanol

Procedimiento

To a solution of 12 (1.93 g, 0.012 mol) in acetone (50 ml) was added hydrogen chloride in ether until acidic reaction. The precipitate was filtered off, dried, and dissolved in methanol (25 ml). 5% palladium on charcoal (0.6 g) was added, and the mixture was shaked overnight under 3 atm. of hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. Crystallization from ethanol yielded 0.63 g (0.0031 mol, 26%) of title product M.P. 168°-172° C. Anal. (C7H14ClN5) C, H, N.

Fuente