Reacción #167914

Ecuación de reacción

6-chloro-2-(4-fluorophenyl)-3-(2-methoxypyrid-4-yl)imidazo-[1,2-b]pyridazine

2-(piperazin-1-yl)ethanol

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product

Rendimiento 43.3%

2-{4-[2-(4-Fluorophenyl)-3-(2-methoxypyrid-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol

Rendimiento 43.3%

Disolventes

pentanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent is then evaporated off under reduced pressure
2. 2
   Otrothe oily residue is chromatographed on a column of silica gel
3. 3
   Lavadoeluting with a stepwise gradient of methanol and aqueous ammonia in dichloromethane (0/0/100 to 2/1/98)

Procedimiento

A mixture of 0.25 g (0.70 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(2-methoxypyrid-4-yl)imidazo-[1,2-b]pyridazine and 0.37 g (2.8 mmol) of 2-(piperazin-1-yl)ethanol in 6 mL of pentanol is stirred at 135° C. for 18 hours. The solvent is then evaporated off under reduced pressure and the oily residue is chromatographed on a column of silica gel, eluting with a stepwise gradient of methanol and aqueous ammonia in dichloromethane (0/0/100 to 2/1/98). 0.136 g of product is isolated after trituration in diisopropyl ether, filtering off and drying under reduced pressure.

Fuente