Reacción #167786

Ecuación de reacción

(S)-2-chloro-8-trifluoromethyl-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one

morpholine

→

(S)-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter one and a half hours of heating
2. 2
   TemperaturaAfter cooling
3. 3
   Concentraciónthe reaction mixture is concentrated under reduced pressure
4. 4
   workup.ADDITION10 ml of cold water and 100 ml of ethyl acetate are added to the residue
5. 5
   Otroobtained
6. 6
   OtroThe resulting organic phase is separated
7. 7
   Secadodried over magnesium sulphate
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated under reduced pressure so as

Procedimiento

A mixture of 1 g of (S)-2-chloro-8-trifluoromethyl-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one and of 15 ml of morpholine is heated at 80° C. After one and a half hours of heating and after verification by LC/MS, the reaction is complete. After cooling, the reaction mixture is concentrated under reduced pressure. 10 ml of cold water and 100 ml of ethyl acetate are added to the residue obtained. The resulting organic phase is separated and then dried over magnesium sulphate, filtered, and concentrated under reduced pressure so as to give 1.2 g of (S)-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one, the characteristics of which are the following:

Fuente