Reacción #1677847

Ecuación de reacción

ethyl 5,6,7,8-tetrahydro-7-(1H-imidazol-1-yl)-8-methylene-2-naphthalenecarboxylate

sodium hydroxide

ethanol

→

5,6,7,8-tetrahydro-7-(1H-imidazol-1-yl)-8-methylene-2-naphthalenecarboxylic acid

Rendimiento 84.5%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais heated
2. 2
   Temperaturaunder reflux for 2 hours
3. 3
   OtroThe solution is evaporated
4. 4
   workup.DISSOLUTIONthe residue is dissolved in water
5. 5
   Extracciónis extracted with methylene chlorid
6. 6
   SecadoThe organic layer is dried over sodium sulfate
7. 7
   Otroevaporated

Procedimiento

A mixture of ethyl 5,6,7,8-tetrahydro-7-(1H-imidazol-1-yl)-8-methylene-2-naphthalenecarboxylate (0.46 g), sodium hydroxide (0.8 g), ethanol (40 ml) and water (5 ml) is heated under reflux for 2 hours. The solution is evaporated, the residue is dissolved in water and the solution, acidified with acetic acid, is extracted with methylene chlorid. The organic layer is dried over sodium sulfate and evaporated to give 0.35 g of 5,6,7,8-tetrahydro-7-(1H-imidazol-1-yl)-8-methylene-2-naphthalenecarboxylic acid.

Fuente