Reacción #167382

Ecuación de reacción

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-5-trifluoromethyl-thiophene

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

Rendimiento 65.0%

1-(4-Methylpyridin-3-yl)-3-(5-(trifluoromethyl)thiophen-2-yl)-imidazolidin-2-one

Rendimiento 65.0%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe same reaction conditions
2. 2
   Otroto afford the crude product
3. 3
   OtroPurification by column chromatography on silica gel (2% MeOH in CHCl3)

Procedimiento

Using the same reaction conditions as described in example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 100 mg, 0.5643 mmol) was reacted with 2-bromo-5-trifluoromethyl-thiophene (136.9 mg, 0.5925 mmol), 1,4-dioxane (10 mL), copper iodide (10.75 mg, 0.0564 mmol), trans-1,2-diamino cyclohexane (20.4 mL, 0.1693 mmol) and potassium phosphate (360 mg, 1.693 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 120 mg of the product (65% yield).

Fuente