Reacción #167270

Ecuación de reacción

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

5-iodo-benzothiazole

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

Rendimiento 70.6%

1-Benzothiazol-5-yl-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Rendimiento 70.6%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford the crude product
2. 2
   OtroPurification by column chromatography on silica gel (2% MeOH in DCM)

Procedimiento

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.84650 mmol) was reacted with 5-iodo-benzothiazole (221 mg. 0.84650 mmol), 1,4-dioxane (25 mL), copper iodide (16 mg, 0.084650 mmol), trans-1,2-diamino cyclohexane (29 mg, 0.2539 mmol) and potassium phosphate (538 mg, 2.539 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in DCM) afforded 185 mg of the product (70.6% yield).

Fuente