Reacción #167255

Ecuación de reacción

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-benzothiazole

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Rendimiento 36.5%

1-Benzothiazol-2-yl-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Rendimiento 36.5%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford the crude product
2. 2
   OtroPurification by column chromatography on silica gel (1.5% MeOH in CHCl3)

Procedimiento

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.84 mmol) was reacted with 2-bromo-benzothiazole (179 mg, 0.847 mmol), 1,4-dioxane (10 mL), copper iodide (16 mg, 0.084 mmol), trans-1,2-diamino cyclohexane (28.8 mg, 0.25 mmol) and potassium carbonate (231 mg, 1.68 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% MeOH in CHCl3) afforded 95 mg of the product (36.5% yield).

Fuente