Reacción #167215

Ecuación de reacción

1-pyridin-3-yl-tetrahydro-pyrimidin-2-one

2-bromo-naphthalene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Rendimiento 35.7%

1-Naphthalen-2-yl-3-pyridin-3-yl-tetrahydro-pyrimidin-2-one

Rendimiento 35.7%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford the crude product
2. 2
   OtroPurification by column chromatography on silica gel (1% MeOH in chloroform)

Procedimiento

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-tetrahydro-pyrimidin-2-one (I-10b: 118 mg, 0.724 mmol) was reacted with 2-bromo-naphthalene (150 mg, 0.724 mmol), 1,4-dioxane (5 mL), copper iodide (13.79 mg, 0.0724 mmol), trans-1,2-diamino cyclohexane (24.865 mg, 0.2172 mmol) and potassium carbonate (200 mg, 1.448 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform) afforded 75 mg of the product (35.71% yield).

Fuente