Reacción #167211

Ecuación de reacción

1-pyridin-3-yl-imidazolidin-2-one

6-bromo-quinoline

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Rendimiento 60.1%

1-Pyridin-3-yl-3-quinolin-6-yl-imidazolidin-2-one

Rendimiento 60.1%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford the crude product
2. 2
   OtroPurification by column chromatography on silica gel (1% MeOH in chloroform)

Procedimiento

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-imidazolidin-2-one (I-1b: 117 mg, 0.7215 mmol) was reacted with 6-bromo-quinoline (150 mg, 0.7215 mmol), 1,4-dioxane (5 mL), copper iodide (13 mg, 0.07215 mmol), trans-1,2-diamino cyclohexane (24.78 mg, 0.21645 mmol) and potassium carbonate (199.49 mg, 1.1443 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform), afforded 125 mg of the product (60.09% yield).

Fuente