Reacción #167207

Ecuación de reacción

1-pyridin-3-yl-imidazolidin-2-one

6-iodo-benzothiazole

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Rendimiento 46.0%

1-Benzothiazol-6-yl-3-pyridin-3-yl-imidazolidin-2-one

Rendimiento 46.0%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto afford the crude product
2. 2
   OtroPurification by column chromatography on silica gel (1% MeOH in chloroform)

Procedimiento

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-imidazolidin-2-one (I-1b: 62 mg, 0.3831 mmol) was reacted with 6-iodo-benzothiazole (100 mg, 0.3831 mmol), 1,4-dioxane (10 mL), copper iodide (7 mg, 0.03831 mmol), trans-1,2-diamino cyclohexane (6 mg, 0.5747 mmol) and potassium carbonate (105 mg, 0.7662 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform), afforded 52 mg of the product (46.01% yield).

Fuente