Reacción #167117

Ecuación de reacción

3a,6a-Dihydro-thieno[3,2-b]thiophene-2-carboxylic acid methoxy-methyl-amide

methylmagnesium bromide

→

title compound

Rendimiento 124.9%

1-(3a,6a-Dihydro-thieno[3,2-b]thiophen-2-yl)-ethanone

Rendimiento 124.9%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Otrowas quenched by addition of 10% HCl
3. 3
   ExtracciónThe aqueous phase was extracted with diethyl ether
4. 4
   LavadoThe organic phase was washed with brine
5. 5
   Secadothen dried over MgSO4
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated

Procedimiento

3a,6a-Dihydro-thieno[3,2-b]thiophene-2-carboxylic acid methoxy-methyl-amide (1.955 g, 8.60 mmol) was dissolved in THF. The stirred solution was cooled to 0° C. before methylmagnesium bromide (1.4 M in PhMe, 8.6 mL, 12.04 mmol) was added. The reaction was allowed to gradually warm to RT o/n, then it was quenched by addition of 10% HCl. The aqueous phase was extracted with diethyl ether. The organic phase was washed with brine then dried over MgSO4, filtered and concentrated to afford the title compound (1.98 g, 80%).

Fuente