Reacción #1664813

Ecuación de reacción

furo[3,2-b]-indole-2-carboxylic acid

thionyl chloride

→

furo[3,2-b]indole-2-carbonyl chloride

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe resulting solution was refluxed for 5 hours
2. 2
   Otrothe excess amounts of thionyl chloride and the benzene were evaporated

Procedimiento

To ethyl furo[3,2-b]indole-2-carboxylate (10 g), 10% aqueous sodium hydroxide solution (100 ml) was added, then the mixture was stirred for an hour at 60° C. The resulting solution was acidified with hydrochloric acid, and the precipitate formed was collected by filtration to give furo[3,2-b]indole-2-carboxylic acid (8.5 g). To furo[3,2-b]-indole-2-carboxylic acid (8.5 g), thionyl chloride (40 ml) and benzene (50 ml) were added, the resulting solution was refluxed for 5 hours, and the excess amounts of thionyl chloride and the benzene were evaporated to give furo[3,2-b]indole-2-carbonyl chloride (7.1 g).

Fuente