Reacción #166413

Ecuación de reacción

lithium aluminum hydride

compound 399

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

→

compound 402

Rendimiento 82.7%

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane

Rendimiento 82.7%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter 1.25 hours of reflux the reaction
2. 2
   Otroquenched with water (2.22 mL)
3. 3
   FiltraciónThe remaining solids were filtered off
4. 4
   Concentraciónthe filtrate was concentrated

Procedimiento

To a stirring mixture of lithium aluminum hydride (2.22 g, 58.5 mmol) in tetrahydrofuran (70 mL) was added compound 399 (3.60 g, 13.8 mmol), portionwise over three minutes. After 1.25 hours of reflux the reaction was cooled to room temperature and quenched with water (2.22 mL), then 1N NaOH (2.22 mL), then water (2×2.22 mL). The remaining solids were filtered off, and the filtrate was concentrated to give compound 402 (2.81 g, 82%). LCMS-ESI (POS), M/Z, M+1: Found 247.1, Calculated 247.2.

Fuente