Reacción #165929

Ecuación de reacción

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

Triethyl amine

Hydrogen

→

Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

Rendimiento 98.1%

Disolventes

Ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreaction
2. 2
   OtroReaction mass
3. 3
   Filtraciónwas filtered through hyflow
4. 4
   Concentraciónconcentrated to residue
5. 5
   Filtraciónfiltered
6. 6
   Otroto remove triethylamine HBr salt
7. 7
   ConcentraciónFiltrate was concentrated

Procedimiento

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (8.5 g) was dissolved in Ethanol (85 ml). Triethyl amine (3.66 g) was added to the reaction mass. 5% Palladium on Carbon (0.85 g) was added and reaction was hydrogenated at 4-5 kg pressure of Hydrogen for 8 hrs. Reaction mass was filtered through hyflow and concentrated to residue. This residue was slurried in methyltert-butylether (42 ml) and filtered to remove triethylamine HBr salt. Filtrate was concentrated to get oily residue of Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (yield 6.0 g).

Fuente