Reacción #165751

Ecuación de reacción

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

Rendimiento 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

Rendimiento 70.0%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   Otrothe solvent was removed in vacuo
3. 3
   Otrothe residue triturated with MeOH
4. 4
   FiltraciónThe resultant filtrate was filtered off

Procedimiento

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

Fuente