Reacción #165657

Ecuación de reacción

2-amino-5-methylthiazole

2-(2-bromoethyl)-1,3-dioxolane

→

NH4OH

title compound

3-(2-(1,3-dioxolan-2-yl)ethyl)-5-methylthiazol-2(3H)-imine

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled to ambient temperature
2. 2
   Otropurified via column chromatography (SiO2, 10% methanol in ethyl acetate

Procedimiento

A mixture of 2-amino-5-methylthiazole (1.0 g, 8.7 mmol) and 2-(2-bromoethyl)-1,3-dioxolane (1.1 mL, 8.7 mmol) was warmed to 85° C. and was allowed to stir for 18 hours. The mixture was cooled to ambient temperature and purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 215 (M+H)+.

Fuente