Reacción #164958

Ecuación de reacción

5-amino-4′-methyl-biphenyl-3-carboxylic acid methyl ester

pyridine

acetic anhydride

→

5-acetylamino-4′-methyl-biphenyl-3-carboxylic acid methyl ester

Disolventes

CH2Cl2

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic layer was washed with saturated aqueous CuSO4 solution, brine
2. 2
   Secadodried over anhydrous Na2SO4
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

To a stirred solution of 5-amino-4′-methyl-biphenyl-3-carboxylic acid methyl ester (3.672 mmol, 884.9 mg) and pyridine (36.7 mmol, 3 mL) in 8 mL of dry CH2Cl2 was added acetic anhydride (7.3 mmol) at room temperature. The mixture was stirred at room temperature for 1 hour, then diluted with ethyl acetate (150 mL). The organic layer was washed with saturated aqueous CuSO4 solution, brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to give 5-acetylamino-4′-methyl-biphenyl-3-carboxylic acid methyl ester (quant. Yield), which was used directly in the next step.

Fuente